Thursday, December 26, 2019

Respiratory Distress Syndrome Essay - 779 Words

Faculty of medicine Pediatrics Department Serum Prolactin Levels in Newborns with Respiratory Distress Syndrome Thesis Submitted for partial fulfillment of Master Degree in Pediatrics By Alia Saeed Abdel Maksoud Metwally M.B.B.CH Zagazig University Faculty of Medicine Zagazig University 2017 Introduction Respiratory distress syndrome in premature infants caused by pulmonary surfactant deficiency with incomplete lung development (Santosham et al, 2013). It can also occur as a consequence of neonatal infection (Sinha et al, 2012). According to the degree of prematurity, it occurs in 7% - 50% of neonates. It is also a common emergency responsible for 30% - 40% of newborns hospital admission (Edwards et†¦show more content†¦Up to our knowledge, this study has not been done before in Zagazig University Hospital. But previous studies have demonstrated that Prolactin has a role in lung maturation. We will compare this study with other studies. Research Question: Is prolactin decrease in cases of Respiratory distress syndrome ? Aim of the work: To compare fetal cord serum prolactin levels among healthy newborns and newborns with Respiratory distress syndrome. Objective: 1. To compare fetal cord serum prolactin levels among healthy newborns and newborns with Respiratory distress syndrome. 2. To find out the role of fetal prolactin in lung maturation. Hypothesis: There is a significant correlation between Prolactin levels and Respiratory distress syndrome. Keywords: Newborn, Fetal cord serum prolactin, Respiratory distress syndrome. Materials and Methods: 1-Technical Design: A. Setting: the study will be conducted in neonatal intensive care unit (NICU) at Zagazig University Hospitals. B. Type of study: Case control study. C. Subjects: Assuming that mean  ± SD of prolactin level in cord blood in Respiratory distress syndrome (RDS) newborns and in healthy newborns is (318.2  ± 130.5 vs 410.9  ± 110.5 respectively), so sample size is calculated by OpenEpi to be 54 cases (27 cases in each group) with confidence level 95% and power of test 80%. Group I (the study group): It will includeShow MoreRelatedRespiratory Distress Syndrome Essay1807 Words   |  8 PagesRespiratory distress syndrome (RDS), also known as hyaline membrane disease (HMD), is a disease that predominantly affects premature neonates. It is due to a deficiency in surfactant which is vital in increasing lung compliance, preventing atelectasis at the end of expiration, and promoting the recruitment of collapsed alveoli by reducing surface tension. 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